1842: vierling te Gent.

Elizabeth Vierling 2 and Randall

The P700 chlorophyll a-protein was purified by preparative sodium dodecyl sulfate (SDS) gel electrophoresis from SDS-solubilized barley (Hordewm vulgare L., cv Himalaya) chloroplast membranes. After elution from the gel in the presence of 0.05 to 0.1% Triton X-100, the recovered protein had a chlorophyll/P70. ratio of 50 to 60/1 and contained no chlorophyll b or cytochromes. Analysis of the pol...

Ether anaesthesia, 1842-1900.

Dmd052415 1835..1842

Drug-induced liver injury is the most frequent reason for market withdrawal of approved drugs, and is difficult to predict in animal models. Here, we analyzed transcriptomic data derived from shortand long-term cultured primary human hepatocytes (PHH) exposed to the well known human hepatotoxin chlorpromazine (CPZ). Samples were collected from five PHH cultures after short-term (1 and 3 days) a...

Dmd059352 1834..1842

Acyl glucuronides are reactive electrophilic metabolites implicated in the toxicity of carboxylic acid drugs. Valproyl 1-O-b-acyl glucuronide (VPA-G), which is a major metabolite of valproic acid (VPA), has been linked to the development of oxidative stress in VPA-treated rats. However, relatively little is known about the toxicity of in situ generated VPA-G and its contribution to VPA hepatoto...

The Gent–McWilliams Skew Flux

This paper formulates tracer stirring arising from the Gent–McWilliams (GM) eddy-induced transport in terms of a skew-diffusive flux. A skew-diffusive tracer flux is directed normal to the tracer gradient, which is in contrast to a diffusive tracer flux directed down the tracer gradient. Analysis of the GM skew flux provides an understanding of the physical mechanisms prescribed by GM stirring,...